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diagnosis management leukemia syndrome chronic lymphocytic mds myelodysplastic 1 acute algorithm all anemia anthracycline aplastic apml cancer cardiomyopathy cardiotoxicity cdi
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... ALL (Acute Lymphoblastic ... Transformation: • Complication ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... • Risks: infection ... transformation to acute ... Allogeneic stem cell ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... kinase (BTK) Complications ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
for Standard-Risk ... Acute Lymphoblastic ... Consolidation & CNS ... Cytarabine #ALL ... #timeline #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Consider stem cell ... neutropenic fever) Complications ... progress to MDS or acute ... • Associated PNH ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... thrombocytopenia Complications ... chemotherapy for low-risk ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... Attempt if high risk ... diagnosis #management #hematology ... #oncology
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
of hospitalized pts ... on ABx) → Acute ... Lowest Risk: Tetracyclines ... - produced by all ... CT A/P: Assess complications
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... carries a variable risk ... and reducing the risk ... Syndromes #diagnosis #hematology ... #oncology
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... • Minority of Pts ... Thromboembolic complications ... diagnosis #management #cardiology ... #treatment
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