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diagnosis differential neurology alkaline arterial cerebritis clinical cns crypto cryptococcal elderly embolism emergencies erythematosus geriatrics hemeonc hepatology hyophosphatasia leukemia low
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
disorders, Aseptic Meningitis ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #neurology #rheumatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
prematurely • risk ... membrane into the CNS ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Acquired Risk ... considered in all ... cardiovascular risk ... Venous #Arterial #pathophysiology ... #hematology #differential
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... Transformation: • Complication ... #Leukemia #Hematology ... #Oncology #Diagnosis
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... • Sepsis Complications ... • Mitchell et al ... • Increased risk ... #causes #cardiology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... mg/dL or > 25 % rise ... Treat underlying cause ... interventional radiology ... AML (~20 %) and APL
Differential Diagnosis: New-Onset Seizure in the Elderly STRUCTURAL: • Stroke/TIA, Subdural hematoma, mass • Traumatic Brain Injury
• Traumatic Brain ... INFECTIOUS: • Meningitis ... Patients with all ... tenfold increased risk ... cardiovascular causes
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
Nausea & vomiting ... If a second LP is ... performed, relative risk ... have a higher risk ... #T2 #MRI #Brain
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