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management treatment differential hemeonc mds myelodysplastic alkaline alp arterial cardiomyopathy chronic cll coagulation dic disseminated embolism emergencies hepatology hyophosphatasia intravascular
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... • Risks: infection ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... Transformation: • Complication ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... thrombocytopenia Complications ... chemotherapy for low-risk ... #oncology #hematology ... #hemeonc #diagnosis
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... • Acquired Risk ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
and Pathophysiology ... • Sepsis Complications ... • Increased risk ... #Pathophysiology ... #causes #cardiology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... protein C and S Pathophysiology ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... prematurely • risk ... membrane into the CNS ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Differential Diagnosis ... Thromboembolic complications ... Cardiomyopathy #diagnosis ... #management #cardiology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... mg/dL or > 25 % rise ... Treat underlying cause ... Usually myeloid leukemias ... #HemeOnc #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
carries a variable risk ... • Hairy Cell Leukemia ... and reducing the risk ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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