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diagnosis differential management algorithm oncology anemia hemolytic thrombocytopenia comparison intravascular table aflp disease disorders extravascular hellp leukemia mds myelodysplastic obstetrics
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Hemolytic #Anemia ... #Differential #Causes ... #Workup #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... uremic syndrome ... hemoglobinuria (PNH ... differential #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Diagnosis #Algorithm #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Intravascular Hemolysis ... • PCH • PNH ... Diagnosis #Algorithm #Causes ... #Hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... thrombocytopenic purpura/hemolytic ... uremic syndrome ... thrombocytopenia, Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... • Risks: infection ... only curative treatment ... #hematology #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... platelet decrease - PNH ... ARUPConsult @ARUPLabs #Hemolytic ... Diagnosis #Algorithm #workup ... #hematology #testing
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... Differential #Diagnosis #Causes ... #hematology #secondary
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Liver Disease, PNH ... Urobilinogen #Hemolysis ... Differential #Diagnosis #hematology
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