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diagnosis differential algorithm rheumatology systemic management thrombocytosis erythrocytosis generalized hemolytic palpable petechiae pruritus purpura syndrome activation agglutinin alkaline alp atlas
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Post-splenectomy Primary ... thrombocythemia (ET) • Polycythemia ... #hematology #secondary
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... thrombocytosis • Polycythemia ... Myelogenous Leukemia • Primary ... Iron deficiency anemia ... #Hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... Thrombocythemia • Polycythemia ... Vera • Primary ... Differential #Diagnosis #causes ... #Platelets #hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Water - Pus ... Barre - ALS - Transverse ... myelitis • Hematology ... : - Anemia • ... #pulmonary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Causes == Primary ... renal failure/uremia ... • Leukemia • Polycythemia ... #secondary #systemic ... #generalized #dermatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Better call hematology ... up EPO levels Primary ... JAK2 V617F) and MPNs ... Algorithm #workup #hematology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Splenomegaly, Increased PMNs ... Cyanosis without Pulmonary ... Apnea • Chronic Pulmonary ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... Diagnosis #Algorithm #Causes ... #Hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
Vera Secondary ... Polycythemia - ... Acquired Causes: ... Hypoxia-driven: Cardiac/pulmonary ... Diagnosis #Algorithm #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... : ITP • Secondary ... - Hemolytic anemia ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
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