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diagnosis differential treatment algorithm sle syndrome erythematosus systemic vasculitis classification comparison dermatology druginduced intravascular polycythemia summary table activation anemia antinxp2
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Tamponade Pulmonary ... - Water - Pus ... Barre - ALS - Transverse ... myelitis • Hematology ... #pulmonary
Algorithm for the Evaluation and Management of Sickle Cell Crises Clinical Manifestations and Management #Diagnosis #Management #Hematology #SickleCell
Evaluation and Management ... of Sickle Cell Crises ... #Diagnosis #Management ... #Hematology #SickleCell ... Manifestations #Workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... • Immunologic Workup ... Positive in 60-80% of cases ... #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology ... cerebritis #diagnosis #management
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... SLE : systemic lupus ... Comparison #Table #Pulmonary ... #Rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... With associated pulmonary ... diagnosis #algorithm #rheumatology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
suspected) • In case ... • Special cases ... Measurement #SLE #rheumatology ... pharmacology #levels #lupus ... #management
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Splenomegaly, Increased PMNs ... Cyanosis without Pulmonary ... Apnea • Chronic Pulmonary ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... Extravascular #Causes ... differential #diagnosis #hematology
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