11 results
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Rhabdomyolysis • Tumor ... lysis syndrome ... glycosides • High ... acute iatrogenic ... blockers - MCW Nephrology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... : • IV fluids ... #Lysis #Syndrome ... #TLS #oncology ... #management #UricAcid
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... Hypomagnesemia, Acute ... and lymphomas, IV ... #Causes #differential ... #diagnosis #nephrology
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... excretion • Acute ... lysis/hemolysis ... #nephrology #potassium ... #differential
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... • Triggers: Diuretics ... - ACS, AKI, acute ... Lysis Syndrome: ... #Lysis #Syndrome
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
malignancies Treatment ... lysis syndrome ... #AKI #Cancer #Oncology ... #Differential # ... #Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... • K sparing diuretics ... Transfusion reaction - Tumor ... lysis syndrome ... #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... • K sparing diuretics ... Transfusion reaction - Tumor ... lysis syndrome ... #nephrology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
• Attempt if high ... Supportive Care: Diuresis ... #APML #diagnosis ... #management #hematology ... #oncology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
urinary losses: • High ... Renin secreting tumor ... #diagnosis #Algorithm ... #differential # ... potassium #nephrology