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diagnosis differential algorithm causes management workup cirrhosis hemolytic oncology pbc primary biliary pathophysiology laboratory liver treatment disease interpretation intravascular lfts
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Decreased RBC ... Thalassemia • RBC ... Disorder • RBC ... Algorithm #Causes #Hematology
Pathophysiology of Hemolytic Anemia - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects) -
Pathophysiology of Hemolytic Anemia ... - Defects in RBC ... - Defects in RBC ... Pathophysiology #Hemolytic #Anemia ... #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... RBC) Morphology ... Microcytic RBC: ... disease, McLeod blood ... differential #diagnosis #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Normocytic #Anemia ... Algorithm #Causes #Hematology
ABO Blood Types and Transfusion Compatibility Table A Blood Type: • RBC Antigens: A • Antibodies: Anti-B
Type: • RBC Antigens ... Type: • RBC Antigens ... Type: • RBC Antigens ... Type: • RBC Antigens ... Compatibility #Table #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
(MCV): Average RBC ... wide range of RBC ... in peripheral blood ... High in acute blood ... Diagnosis #Workup #Hematology
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... Severe hemolytic anemia ... , Hemolytic anemia ... Sickle cell, MDS #RBC ... Bodies #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... 3) Internal (RBC ... Defects: Sickle cell anemia ... - Peripheral Blood ... Differential #Diagnosis #hematology
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency Anemia ... Tests: • MCV/RBC ... - RBC ↓ in proportion ... carrying component of blood ... Fe #diagnosis #hematology
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