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hematology differential algorithm anemia treatment causes hepatology workup criticalcare atlas hematuria morphology smear syndrome hemolytic infection macrocytic macrocytosis medications microscopy
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Algorithm Blood ... Decreased RBC ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
directed donations) - RBC ... Hct of 70-80% - RBC ... plasma, a few RBC ... ofplasma, a few RBC ... Volume #Hematology #Management
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... RBC) Morphology ... Microcytic RBC: ... disease, McLeod blood ... #differential #diagnosis
Red Blood Cell Morphology Atlas Size variation, Hemoglobin distribution, Hypochromia, Shape variation, Inclusions, Red
Red Blood Cell Morphology ... distribution #Diagnosis ... #Path #Blood #Smear ... #RBC #Morphology
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Pathologic Red Blood ... Cell (RBC) Morphologies ... cell, Other RBC ... Howell-Jolly bodies #RBC ... Pathology #Hematology #Diagnosis
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... turnover • Acute blood ... Dilutional Effect • RBC
Plasmodium falciparum life cycle 1: Mosquito bite, transmission of sporozoite 2: Liver, Asexual replication. 1 sporozoite → 10-30,000
merozoites 3: Blood ... Merozoites infect RBC ... RBC ruptures releasing ... Merozoites infect other RBCs ... falciparum #lifecycle #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... 2) External (RBC ... 3) Internal (RBC ... - Peripheral Blood ... #Differential #Diagnosis
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... wide range of RBC ... in peripheral blood ... High in acute blood
Hyperkalemia Differential Diagnosis Algorithm R/O Pseudo-hyperkalemia: • Possible Lab error! Alwavs Repeat Blood sample! • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential Diagnosis ... Alwavs Repeat Blood ... while drawing blood ... ischemia-induced RBC ... hemolysis) • RBC
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