51 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Anemias (AIHAs) ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology of Hemolytic ... Anemia - Defects ... in RBC internal ... - Defects in RBC ... #Anemia #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Reticulocytosis • Primary ... Bleed • Hemolysis ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... Algorithm #Causes #Hematology
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Liver Disease: Primary ... Biliary Cirrhosis vs Primary ... pathophysiology #pbc ... #psc #hepatology
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Common RBC Inclusions ... Asplenism, Severe hemolytic ... , Hemolytic anemia ... Sickle cell, MDS #RBC ... Bodies #diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... Microangiopathic Hemolytic ... Bite Cell RBC: G6PD ... differential #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgM) (e.g. primary ... • Intrinsic RBC ... differential #diagnosis #hematology ... #anemia
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... breakdown • Anaemia ... Urobilinogen • + urinary ... #Hemolytic #Anemia ... Causes #Workup #Hematology
Summary table of comparison of the difference between primary biliary cholangitis (PBC) and primary sclerosing cholangitis
difference between primary ... biliary cholangitis (PBC ... ) and primary sclerosing ... cholangitis (PSC ... #differential #hepatology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... Anemia 1) DIAGNOSE ... AIHA • Anemia ... ↑ LDH • Anti-RBC ... management #treatment #rheumatology