37 results
diagnosis hematology differential oncology treatment causes algorithm leukemia microbiology alopecia anemia blood chronic diffuse gastroenterology hairloss hemeonc hemolysis hemolytic lymphocytic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... develop leukostasis syndrome ... • Peripheral smear ... • Tumor lysis syndrome ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... • Peripheral smear ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Peripheral Smear ... → Refer to hematology ... Kawasaki, Nephrotic syndrome ... pancreatitis, Post-surgical ... Others: Asplenia/post-splenectomy
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Post-Transplantation ... hematopoietic cell ... , intensity of induction ... #Post #Transplantation ... oncology #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Cold-induced symptoms - most ... IgM) • Blood smear ... Polyclonal IgM post ... hemolytic #anemia #hematology
Disseminated Gonococcal Infection - Diagnosis and Management Summary Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
Diagnosis and Management ... Arthritis-Dermatitis syndrome ... Purulent Arthritis Syndrome ... : • Most patients ... #Microbiology #InfectiousDiseases
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... ) (e.g. lupus, CLL ... antibiotics are the most ... spherocytosis) • Infections
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Internal (RBC) - Infections ... Defects: Sickle cell ... Peripheral Blood Smear ... Differential #Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... sarcoidosis) • Post-splenectomy ... Myelodysplastic syndrome ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... risk-stratification • Risks: infection ... Allogeneic stem cell ... Myelodysplastic #Syndrome ... #treatment #hematology
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