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diagnosis differential treatment hematology oncology algorithm microbiology classification neurology rheumatology anesthesia anesthesiology checklist dermatology intraoperative anemia chronic clinical hiv leukemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... Malaise, bleeding, infections ... pain, bleeding, infections ... bruising, bleeding, infection ... • Peripheral smear
Disseminated Gonococcal Infection - Diagnosis and Management Summary Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
Disseminated Gonococcal Infection ... symptomatic genital infection ... typically part of the workup ... Disseminated #Gonococcal #Infection ... #Microbiology #InfectiousDiseases
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Peripheral Smear ... hematology for workup ... TPO, TPO-RA • Infections ... : Chronic infections ... bacterial and viral infections
Ear Pain (Otalgia) - Differential Diagnosis Framework Primary Otalgia - Pain that originates from the ear
associated with infection ... by bacterial infections ... (90%), Fungal infections ... • Dental infections ... • Dental infections
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
Most invasive infections ... are caused by members ... Rhinosinusitis, CNS infection ... , Disseminated infection ... systemic vori Infectious
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Acquired HLH: • Infections ... Still disease, Infection ... Drugs, Unknown cause ... Etiological+++: Anti-infectious
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... ) (e.g. lupus, CLL ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... • Peripheral smear ... • Richter’s Syndrome ... Leukemia #diagnosis #workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Polyclonal - Viral Infection ... Check For: • Infections ... Polyclonal IgM post ... infectious setting
Causes of Severe Aortic Regurgitation - Differential Diagnosis Acute: • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Causes of Severe ... Valve Dysfunction, Post ... - Leaflet: • Infection ... Inflammatory: Infectious ... Salmonella), Giant Cell
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