18 results
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm

aPTT: Intrinsic / Final
PT: Extrinsic / Final

By
- Differential Diagnosis ... Algorithm aPTT ... Matthew Ho, MD PhD ... INR #Algorithm #Hematology ... #differential #diagnosis
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... • Vitamin K deficiency ... • Factor VII deficiency ... Thromboplastin #laboratory #hematology ... #diagnosis
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
• 812, Folate Deficiency ... Matthew Ho, MD PhD ... #differential #diagnosis ... #algorithm #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT ... Matthew Ho, MD PhD ... Management #Algorithm #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Acute hemolysis, deficiency ... Inflammatory Conditions: Rheumatologic ... Matthew Ho, MD PhD ... #Algorithm #hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
clotting factor deficiency ... PT and/or aPTT) ... Mixing #Study #diagnosis ... #hematology #pathophysiology ... #hematology #laboratory
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Prolonged PT and aPTT ... the PT and the aPTT ... Prolonged #Causes #diagnosis ... #differential #hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
- Differential Diagnosis ... iron studies, PT/aPTT ... Differential Diagnosis ... Matthew Ho, MD PhD ... #Algorithm #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
- Differential Diagnosis ... Table Warm AIHA ... Matthew Ho, MD PhD ... #Differential #Diagnosis ... #Table #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... Acquired deficiency ... Congenital deficiency ... Prolonged #Causes #diagnosis ... #differential #hematology