26 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome ... Clinical Presentation ... anemiaCold ... younger pts) Differential ... chills, flank pain
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... Extravascular #Causes #differential ... #anemia
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH, Evans Syndrome ... Internal (RBC) - Infections ... Defects: Sickle cell anemia
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... Spinal cord ... Infarction - Infection ... #differential # ... diagnosis #neurology
Vascular Joint Pain - Differential Diagnosis Algorithm 
 - Constant Pain (Ischemia)
 - Acute Onset
 -
- Differential ... Claudication) - Cold ... • Sickle Cell Anemia ... Peripheral Vascular Disease ... Marfan's Syndrome
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
Spinal Cord Disorders ... Spinal cord ... neurological lesion: Clinical ... Infections: - ... MCTD, Sjogren syndrome
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
of the spinal cord ... Transverse Myelitis - Clinical ... or without back pain ... Transverse Myelitis Treatment ... management #neurology #differential
Cauda Equina Syndrome Overview

Cauda Equina Syndrome:
 • Prevalence: 1:33,000-100,000 ppl/yr
 • Incidence: 1.5-3.4 million ppl/yr
 •
Diagnosis: • ... Spinal cord infarct ... spondylitis • Tethered cord ... axial T1 and T2 Treatment ... #differential #
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
meninges in spinal cord ... nerve roots Spinal Cord ... lesion Pott's Disease ... #Tuberculosis #diagnosis ... #differential #
Bronchiectasis - Summary

What?
• Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
weight • Chest pain ... obstruction • COPD ... mycobacteria Treatment ... Bronchiectasis #pulmonary #differential ... #diagnosis