28 results
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Differential Diagnosis Algorithm ... CD13, CD33, CD34, HLA-DR ... - T-cell - CD7 ... , CD3 Chronic ... Differential #Diagnosis #Algorithm
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... ) Pathophysiology ... →Activation of CD8 ... • Clinical: fever ... • Familial HLH
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
HLA-DR4 mutation ... GCA is almost never ... /Symptoms: - Fever ... Temporal #Arteritis #Pathophysiology
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic Algorithm ... Pathophysiology ... - Pathophysiology ... instability - New-onset fever ... Color #Targetoid #Algorithm
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
Fever of Unknown ... Refer to your ‘Fever ... Returning Traveler’ algorithm ... respective fungal pathogens ... udaygulati #FUO #Fever
Management Algorithm for Confusion
- Substrate verification, glucose, oxygen checks
- Toxidrome present
- Focal findings on neurologic examination
-
Management Algorithm ... examination - Fever ... examination, basic (CBC ... Delirium #Management #Algorithm
Cellular and humoral immune responses of the adaptive immune system. Activated T cells accomplish cellular immune
associated with CD4 ... or CD8, depending ... intracellular pathogen ... ImmuneResponses #immunology #pathophysiology
Algorithm for Management of Acute Exacerbation of COPD (AECOPD)

Obtain workup for alternate diagnoses and relevant comorbidities:
Algorithm for Management ... comorbidities: • CBC ... respiratory viral pathogen ... #COPD #AECOPD #Algorithm
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
produced from pathogens ... present Ag to CD4 ... Opsonization: Abs coat pathogens ... Neutralization: Abs bind to pathogen ... Humoral #Immunity #pathophysiology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic Fever ... auto-reactive B and CD ... inflammation • Fever ... RheumaticFever #pathophysiology