12 results
Disorders of Pigmentations - Hypopigmentation and Hyperpigmentation - Differential Diagnosis Algorithm

HYPOPIGMENTATION
Diffuse Congenital - Generalized hypopigmentation of
• Addison's disease ... McCune Albright syndrome ... #disorders #skin ... #dermatology #Differential ... #causes
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... appearing during the disease ... #differential # ... diagnosis #dermatology ... #oncology #clinical
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... EGPA • Solid cancers ... #manifestations ... #pathology #lesions ... #differential
Skin Hyperpigmentation - Differential Diagnosis Algorithm
Diffuse:
 • Tanning
 • Adverse cutaneous drug eruption
 • Addison's disease
Skin Hyperpigmentation ... • Addison's disease ... #disorders #skin ... #dermatology #Differential ... #causes
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Manifestations: ... gangrenosum • Cutaneous ... hypertrichosis, hyperpigmentation ... anemia due to cold ... #Monoclonal #Differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... Skin lesions ... Rarely dominate the clinical ... • Goodpasture syndrome
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Manifestations: ... ) • Cutaneous Lesions ... (Clinical Dx). ... ) Differential Diagnosis ... : monoclonal TNF-aIpha
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Agglutinin Syndrome ... Viral Infection Clinical ... presentation) • Cutaneous ... younger pts) Differential
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Rare Disorder: ... Most common extra cutaneous ... Causes: - Idiopathic ... #diagnosis #dermatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... Manifestations ... cryoglobulins • Negative causes ... Biopsy: Typical pathologic ... Antiphospholipid syndrome