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hematology differential management oncology aplastic bloodsmear borrelia cauda caudaequina chronic clinical cll coagulation dic disseminated elevatedmcv equina extravascular hemolysis leukemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Algorithm Extravascular ... immune-complex hemolytic anemia ... • Acute HTR ... #Algorithm #Causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Myelodysplastic Syndromes ... Cells, Normal WBCs ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... effect following treatment ... Iron deficiency anemia ... #Algorithm #Causes ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... • ↓ WBC • ↓ ... Treatment: ... may result from low ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... - ACS, AKI, acute ... , Elevated Cr, Low ... #TLS #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... malignancy (Especially acute ... Prolonged PT/PTT • Low ... #Coagulation #diagnosis ... #causes #treatment
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
Hgb 12.5, WBC 14 ... Syndrome: 3d of ... LBRF can be diagnosed ... Given low sensitivity ... BloodSmear #microscopy #pathology
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
spine • MCC- acute ... symptoms: • Severe low ... - Emergency Causes ... axial T1 and T2 Treatment ... #causes #neurology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Confirm: Flow ... • Neutropenia, anemia ... microglobulin Treatment ... ’s lymphoma or acute
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