24 results
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... #Autoimmune #Hemolytic ... #Anemia #Pathophysiology ... #diagnosis #hematology
Pathophysiology, Signs and Symptoms of Hemolytic Anemia

#Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, ... Signs and Symptoms ... of Hemolytic Anemia ... #Hemolytic #Anemia ... #hematology #diagnosis
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... #Anemia #AIHA # ... Treatment #management ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) - HELLP syndrome ... uremic syndrome ... differential #diagnosis #hematology ... #anemia
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Differential #Diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
women • 15% of AIHA ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... anemia • Cold ... #anemia #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
immunophenotype Clinical ... cytopenias (ITP, AIHA ... AIHA, PRCA) • Treatment ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Autoantibodies: • WAIHA ... Coagulopathy) SMZL: • AIHA ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... Demyelinating syndromes ... ) Blood (75%): Anemia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... : • Pathophysiology ... TLS #diagnosis #management ... #hematology