15 results
Complement Pathways
- Classical Pathway
- Lectin Pathway
- Alternative Pathway

#Complement #Pathway #hematology #pathophysiology
Complement Pathways ... - Classical Pathway ... - Lectin Pathway ... #Pathway #hematology ... #pathophysiology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Vasculitis #HUV #Pathophysiology ... #Rheumatology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... formation along glomerular ... staining (lg + complement ... MGPN • Complement ... pathway • C3
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
BEARING CHILD PATHWAY ... FLAGS - In all cases ... cell disease Rheumatology ... #Limping #NWB #Algorithm ... #Pathway #Child
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... differential #diagnosis #algorithm ... #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... • Inflammatory Pathway ... cyclophosphamide • Ischemic Pathway ... CNS #neurology #rheumatology
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... pathways. ... infections are common causes ... of glomerular disease
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
and intrinsic pathways ... Initiation phase caused ... models (i.e. common pathway ... diagnosis #models #hematology ... #pathophysiology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... About CPPD When ... disease states Pathophysiology ... activate inflammatory pathways ... Gout #Comparison #rheumatology
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... pathways. 6) SPEP ... infections are common causes ... #glomerular #disease