PatientInfo table treatment diagnosis hematology lupus rheumatology syndrome thrombocytopenia classification systemic symptoms autoantibodies myositis antinuclear

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Autoantibodies in Rheumatology
• Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and

Rheumatology • ... Peptide (CCP) • Myositis ... • Scleroderma (Systemic ... #Rheumatology # ... #table

Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin

Demyelinating syndromes ... Glomerulonephritis Myositis ... #Lupus #SLE #systemic ... erythematosus #signs #symptoms ... #diagnosis #rheumatology

Systemic Lupus Erythematosus - Diagnosis
Manifestations:
- Arthritis 69%
- Malar rash 40%
- Fever 36%
-

Systemic Lupus Erythematosus ... anemia 4% - Myositis ... #Diagnosis #autoantibodies ... #signs #symptoms ... #differential #rheumatology

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... context of other symptoms ... , Myositis, Mixed ... ANA #patterns #rheumatology ... #diagnosis #differential

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

and Systemic lupus ... #autoantibodies ... #Systemic #lupus ... #rheumatology # ... table #ANA

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... Skin Disease Classification ... • Anti-Ro/SSA autoantibodies ... : • Symptoms limited ... #Diagnosis #Rheumatology

Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
• Epidemiology: -10% of all lupus cases, drug-dependent,

months) and of autoantibodies ... months to years) Systemic ... sle #comparison #table ... #rheumatology # ... diagnosis #management

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

inflammation Others: • Lupus ... lupus erythematosus ... Symptoms (Sx) in ... #rheumatology # ... classification

TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome

lupus erythematosus ... symptoms Histopathological ... Diagnoses - The ... Hypoalbuminemia Treatment ... #management #rheumatology

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