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oncology algorithm causes cll leukemia lymphocytic management thrombocytosis classification extravascular hemeonc hemolysis hodgkins index intravascular lymphoma mds myelodysplasia myelodysplastic platelets
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... , deficiency anemia ... : Chronic infections ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... within circulation ... - Infections ... anemia • ... #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
: Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... malignancies • Anemia ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... inclusions - If infection ... elliptocytosis, autoimmune ... #Anemia #Differential ... #workup #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... hypertension and/or drug treatment ... - Autoimmune neutropenia ... Megaloblastic anemia-rare ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... 5) Symptoms of anemia ... Complications: 1) Infection ... neutropenia) ... Leukemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... , anemia, thrombocytopenia ... microglobulin Treatment ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Myeloproliferative Disease • Neutropenia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... Hodgkin Lymphoma Treatment ... classification #hematology
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