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oncology anemia algorithm causes leukemia management cll lymphocytic thrombocytosis agglutinin atlas bloodcell calculation classification cold common cvid disease erythematosus extravascular
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... : Chronic infections ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... e.g. lupus, CLL, lymphoma ... idiopathic) - Autoimmune ... Extravascular #Causes #differential ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Leukemia • Lymphoma ... Inflammatory and Autoimmune ... Antibody-mediated hemolysis ... deficiency Infections ... #Diagnosis #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... Thrombocytosis): • Acute infection ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... inclusions - If infection ... elliptocytosis, autoimmune ... #workup #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... Diagnosis Neonate ... hypertension and/or drug treatment ... - Autoimmune neutropenia ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
: Autoimmune, Microangiopathic ... hemolytic anemia ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
spherocytosis, Autoimmune ... IgM associated lymphoma ... disease, Malignant lymphoma ... RBC #Morphology #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Complications: 1) Infection ... neutropenia) ... to large cell lymphoma ... Leukemia #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
, autoimmune disorder ... or lymphoid malignancy ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
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