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oncology algorithm lymphocytic thrombocytosis workup agglutinin basophilia basophils classification cold hemeonc hemolytic hodgkins lymphoma mds myelodysplasia myelodysplastic neutropenia platelet platelets
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia ... Myelofibrosis Infectious ... • Rheumatic disorders ... • Celiac disease ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... , bleeding, infections ... #Hematology #Oncology ... #Diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... , Vasculitides, ... : Chronic infections ... #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... : • Chronic myeloid ... leukemia (CML) ... #Diagnosis #causes ... #hematology #basophils
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... Physical Exam/Signs ... • Neutropenia, anemia ... #Leukemia #diagnosis ... workup #oncology #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Megaloblastic anemia-rare ... including white blood ... #diagnosis #causes ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
procedures - Infection ... plateletcount), peripheral blood ... changes), high MCV anemia ... Diagnosis #Causes ... #Workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... younger pts) Differential ... sensitize red blood ... chills, flank pain ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... in adults • Disorder ... Complications: 1) Infection ... #hematology #hemeonc ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood ... cell count (anemia ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #hematology #oncology
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