12 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... , Vasculitides, ... : Chronic infections ... #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... #Anemia #diagnosis ... #management #treatment ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... , bleeding, infections ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
kidney disease, ... marrow failure: Aplastic ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
weeks without infection ... Physical Exam/Signs ... • Neutropenia, anemia ... aplasia • ITP ... workup #oncology #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... younger pts) Differential ... sensitize red blood ... chills, flank pain ... #hematology #diagnosis
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
hypertension and/or drug treatment ... Megaloblastic anemia-rare ... including white blood ... cell aplasia DOI ... #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... • Aplastic Anemia ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #hematology #oncology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
: Fever, flank pain ... due to marrow aplasia ... coagulopathy & ↑bleeding ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
: Fever, flank pain ... due to marrow aplasia ... coagulopathy & ↑bleeding ... #Transfusions #diagnosis ... #management #hematology