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algorithm management oncology causes eosinophils apml dermatology disorders eosinophil hodgkins hypereosinophilic lymphoma monoclonal nonpalpable palpable paraproteinemias platelets purpura thrombocytopenia thrombocytosis
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Relevant HES Variants ... and Treatment Algorithm ... #Syndrome #HES ... #Hematology #eosinophilia ... #eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
Syndrome (HES) ... hypersensitivity - Infection ... #Syndrome #HES ... #eosinophilia #diagnosis ... #hematology #differential
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- Differential ... Asthma Tugs (vasculitis ... Leukemia - Primary Hypereosinophilic ... Syndrome - Chronic ... #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
/hypereosinophilia ... drug reaction, infection ... glucocorticoid treatment ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... , Vasculitides, ... Kawasaki, Nephrotic syndrome ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... DIC • Vasculitis ... • Infection ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... Kasabach-Merritt syndrome ... #Diagnosis #hematology ... #rheumatology #
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation ... Syndrome in APML ... initiation • Differential ... Diagnosis: Infection ... #hematology #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... to exclude are infections ... differential #diagnosis ... #rheumatology # ... classification
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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