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management syndrome tls lysis cell classification emergencies gammopathy hemeonc hodgkins hyperkalemia k leukostasis lymphoma mgrs monoclonal nephrology oncologic plasmacytoma renal
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
≥ 8 mg/dL • Potassium ... of the above Treatment ... abnormalities • Cardiac ... Lysis #Syndrome #diagnosis ... #management #oncology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor ... 8.0 mg/dL • Potassium ... age and sex) • Cardiac ... Syndrome #TLS #diagnosis ... #management #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
lethargy, hematuria, cardiac ... unless worrisome EKG ... with tetany or cardiac ... Syndrome #TLS #diagnosis ... #management #hematology
Shock - Diagnosis and Management Summary • Hypotension: SBP<90, SBP drop >40, MAP<65 (Normotension, HTN possible
Shock - Diagnosis ... telemetry, 12-Lead EKG ... Cardiac surgery? ... Management #Summary #criticalcare ... #treatment #workup
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
octreotide), hyperK periodic ... reabsorption) Workup ... heparinized tube) • ECG ... line, stabilizes cardiac ... #potassium #nephrology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
predominant HL - The tumor ... Hodgkin Lymphoma Workup ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... antibiotics TLS (tumor-lysis ... syndrome): - Hematologic ... #HemeOnc #Diagnosis
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
light-chain ratio Diagnostic ... Workup: • Kidney ... Kidneys • Low Tumor ... microangiopathy Treatment ... #Significance #Diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
red bone marrow, e.g ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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