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diagnosis algorithm workup arthritis diffuse joint lad lymphadenopathy msk pain thrombocytopenia anemia aplastic approach chronic classification cll disorders enlarged erythematosus
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Non-infectious (malignancy, rheumatologic ... Chronic Myeloid Leukemia ... Diagnosis #causes ... #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential ... Chronic Myelogenous Leukemia ... #Differential # ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... Chronic myeloid leukemia ... #Differential # ... #hematology #secondary
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... Lymphadenopathy - Differential ... • Neoplastic (Leukemia ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Lymphadenopathy - Differential ... Pancytopenia, WBC differential ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... • Lymphoma • Leukemia ... vera, essential thrombocytosis ... Spleen #Enlarged #Differential ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blasts in the peripheral ... -> AML: Blast crises ... maturation • (Peripheral ... basophilia, and thrombocytosis ... #Hematology #Oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Leukemia, Tumour ... Autoimmune • ITP • SLE ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... plateletcount), peripheral ... test, ANA (e.g., SLE ... or if a primary hematologic ... #Workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... non-Hodgkin lymphoma SLL ... cytometry • Peripheral ... diagnosis #workup #oncology ... #hematology
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