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rheumatology lupus sle dermatology disease activation adultonset antinxp2 antinxp2dm arthritis canimorsus capnocytophaga clues common comparison cvid dermatomyositis druginduced hypogammaglobulinemia immunodeficiency
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Photosensitivity, Butterfly rash ... ) Blood (75%): Anemia ... #erythematosus ... signs #symptoms #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... Differential Diagnosis ... (NPSLE): • May ... lymphopenia, low PLT • Anemia ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... Petechial or purpuric rash ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
especially in the wrists ... when infection has ... #sle #clues #system ... #erythematosus ... #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... arthritis, Skin rash ... solid cancers • Systemic ... Complications: MAS ... #management #treatment
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... months to years) Systemic ... Lupus Erythematosus ... #diagnosis #management
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
air conditioning system ... Bandemia, AKI. ... possible Patient's clinical ... the key to the diagnosis ... #dermatology #clinical
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
years Clinical ... autoimmune hemolytic anemia ... ) • Systemic granulomatous ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... lupus erythematosus ... the presence of anemia ... (to support a diagnosis ... ANA and RF (if clinical
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