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differential anemia oncology rheumatology aiha algorithm blood causes chronic cll cold leukemia lymphocytic product reactions syndrome vonwillebrand workup acquired agglutinin
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
, Autoimmune disorder ... Spherocytes • Treatment ... • Treatment: Warm ... #hematology #diagnosis ... #comparison
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... - Differential Diagnosis ... Table Warm AIHA ... Cold Agglutinin Disease ... #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... idiopathic) - Autoimmune ... lymphoproliferative disorders ... #differential #diagnosis ... #hematology #anemia
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... esp if severe disease ... #AIHA #Treatment ... #management #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
and Management ... thrombocythemia), Autoimmune ... disease • vWF ... #Management #treatment ... #hematology #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Consider RBC membrane disorder ... elliptocytosis, autoimmune ... #Differential #Diagnosis ... Algorithm #workup #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Advanced Liver Disease ... disorders (e.g. ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
Von Willebrand Disease ... inherited bleeding disorder ... bruising • Skin ... factor VIII) Treatment ... #Diagnosis #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... spherocytosis, Autoimmune ... Agglutinate: Cold autoimmune ... #differential #diagnosis ... #hematology #microscopy
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... DIC/TTP/HUS - Hemolytic ... #hematology #rheumatology ... #nonpalpable #dermatology
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