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oncology algorithm cll intravascular lymphocytic product reactions approach basophilia basophils bleeding bruising disseminated extravascular gap globulin hemeonc hemolysis hemolytic hemostasis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia ... • Rheumatic disorders ... • Celiac disease ... Iron deficiency anemia ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss ... Deficiency • Aplastic ... of Chronic Disease ... #Classification ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
, coagulation disorders ... disorders CAUSES ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... (DIC) - HELLP ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
the total white blood ... Myeloproliferative Disorders ... : • Chronic myeloid ... #Diagnosis #causes ... #hematology #basophils
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... #diagnosis #causes ... #treatment #management ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #hematology #diagnosis ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cells can indicate disease ... • Neutropenia, anemia ... Pure red cell aplasia ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... in adults • Disorder ... chemotherapy for low-risk disease ... #oncology #hematology ... #management
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Megaloblastic anemia-rare ... including white blood ... cell aplasia DOI ... #diagnosis #causes ... #hematology
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