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differential oncology algorithm causes blood cll lymphocytic product thrombocytosis aclf basophilia basophils bleeding bruising cirrhosis common comparison cvid deficiencies deficiency
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia ... Infectious: • Acute ... • Rheumatic disorders ... • Celiac disease ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... • Infections: Chronic ... #Algorithm #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... , coagulation disorders ... deficiency • Liver ... #hematology #rheumatology ... #nonpalpable #dermatology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
- Differential Diagnosis ... Myeloproliferative Disorders ... : • Chronic myeloid ... Colitis and Crohn’s Disease ... #causes #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
) • Advanced Liver ... Malignancy, Autoimmune disorders ... promyelocytic leukemia ... table #comparison #diagnosis ... #hematology #deficiency
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology ... #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
toxic aetiology: Skin ... disease, Hepatic ... dechallenge • Acute ... Hepatic vascular disorder ... #Algorithm #hepatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cells can indicate disease ... microglobulin Treatment ... ’s lymphoma or acute ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... in adults • Disorder ... chemotherapy for low-risk disease ... #oncology #hematology ... #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... promyelocytic leukemia ... DIC • Severe Liver ... #treatment #management ... #hematology
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