8 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... scleroderma) - Anti-Scl ... + 90% • Granulomatosis ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE ... Usual therapeutic management ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Auto-Antibodies: - ANA ... ) 30-45% Differential ... Diagnosis and Lupus ... symptoms #mimickers #differential ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Diagnosis Framework ... glomerulonephritis - Granulomatous ... inflammation Others: • Lupus ... such as systemic lupus ... #diagnosis #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... diagnoses, including ... and aPL) 9) Unexplained ... #diagnosis #sle ... erythematosus #rheumatology
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
joint aches • +ANA ... uncommon 5-15% of lupus ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Non-autoimmune rheumatologic ... #Rheumatology
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... lupus cases, drug-dependent ... #DIL #rheumatology ... #diagnosis #treatment ... #management