22 results
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Drugs that Impair Renal ... Potassium Excretion ... Aldosterone Release: ACE ... Pathophysiology #Pharmacology ... #Renal
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Metolazone) 5) Potassium-sparing ... nephron #diuretics #pharmacology ... #nephrology #medications
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Thyrotoxicosis Medications ... Renal Losses ... Non-renal losses ... Diagnosis #Algorithm #nephrology ... #low #potassium
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... pathophysiology #pharmacology ... #potassium #medications
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Chlorthalidone POTASSIUM-SPARING ... #Diuretics #Medications ... #Pharmacology # ... summary #table #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• NSAIDs • ACE ... • Recent IV potassium ... Medications 2. ... diagnosis #causes #potassium ... #high #nephrology
Pharmacological Treatment of Hepatorenal Syndrome (HRS)

Midodrine - Alpha agonist incr blood pressure incr renal perfusion pressure
pressure incr renal ... edgarvlermamd - Nephrology ... HepatoRenal #Syndrome #Nephrology ... #Management #Pharmacology ... #Medications #Treatment
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• NSAIDs • ACE ... • Recent IV potassium ... Medications 2. ... diagnosis #causes #potassium ... #high #nephrology
Immunosuppression in Transplantation
Induction (I):
 - Basiliximab (Simulect)
 - Alemtuzumab (Campath)
 - Rituximab
 - Anti-Thymocyte Globulin (ATG)
Induction
Immunosuppressive #Medications ... #Pharmacology # ... Maintenance #Management #Nephrology ... #Renal
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
(steatorrhea) Renal ... osmotic diuresis - Potassium ... Tubulointerstitial renal ... #differential #medications ... #drugs #pharmacology