22 results
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Hypernatremia Differential ... Diagnosis Algorithm ... - Diabetes Insipidus ... history Step #2 ... #Sodium #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Hypernatremia - Differential ... insipidus • Nephrogenic ... diabetes insipidus ... Diagnosis #Causes #nephrology ... #sodium #high
Polyuria - Differential Diagnosis Algorithm
Urine Output > 3L /day
Water Diuresis (Urine Osm <100 mOsm/kg)
 • Primary
Polyuria - Differential ... Diagnosis Algorithm ... Insipidus • Nephrogenic ... Diabetes Insipidus ... #causes #nephrology
Diabetes Insipidus - Diagnosis Algorithm
Tests:
 • Osmolality, Urine AND/OR
 • Osmolality, Serum or Plasma AND
 •
Diabetes Insipidus ... Plasma AND • Sodium ... Osmolality, Urine 1-2 ... #Algorithm #nephrology ... #differential
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypernatremia - Differential ... renal mechanism 2) ... • Euvolemic: Diabetes ... insipidus (central ... #nephrology #sodium
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Diagnosis Algorithm ... water loss, Serum Sodium ... 300 mmol/kg • Diabetes ... Insipidus Hypodipsia ... Hypernatremia #Nephrology
Polyuria - Differential Diagnosis Algorithm
Polyuria = >3L Urine output / 24 hours
Urine osmolality = 2 (Na
Diagnosis Algorithm ... Urine osmolality = 2 ... 100 mosm/kg • Diabetes ... Insipidus • Primary ... #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
insipidus: - ... mutations in AQP-2 ... #Diabetes #Insipidus ... Classification #Types #Nephrology ... #Diagnosis #Differential
Causes of Polyuria - Differential Diagnosis Algorithm
Polyuria - Urine Output > 3L/day, Increased Urine Volume (>2ml/min)
Osmotic
of Polyuria - Differential ... Diagnosis Algorithm ... Insipidus - DDAVP ... #Nephrology #Differential ... #Diagnosis #Algorithm
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
of epithelial sodium ... ATPase Nephrogenic diabetes ... insipidus - Vasopressin ... Defects #Kidney #Nephrology ... #Diagnosis #Differential