108 results
Anaplasma Infection - Anaplasma phagocytophilum
Pathophysiology: 
 • Obligate, intracellular bacteria
 • Transmitted via blacklegged tick —
Anaplasma Infection ... phagocytophilum Pathophysiology ... immature forms) • Anemia ... #Anaplasma #Infection ... #diagnosis #microbiology
Causes of Depressed / Lethargic Newborn - Differential Diagnosis Algorithm
Maternal Related:
 • Drugs (Ex. SSRI)
 •
Lethargic Newborn - Differential ... Malformation • TORCH Infection ... Respiratory Distress Syndrome ... Sepsis Other: • Anemia ... Lethargic #Newborn #Differential
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... deficiency Infections ... #Pancytopenia #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... spherocytosis) • Infections ... Extravascular #Causes #differential
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness - Differential ... feel weak": • Infectious ... ILD, OSA, pHTN, Anemia ... Rhabdomyolysis, Critical ... Generalized #Weakness #Differential
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
(eg, hemolytic anemias ... , Rotor syndrome ... eg, spirochetal infections ... , infectious mononucleosis ... #unconjugated #differential
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Erythropoiesis (B12 injections ... in pernicious anemia ... • Refeeding syndrome ... #Hypokalemia #Differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection ... Thrombocytopenia #Differential
Gastrointestinal Causes of Iron Deficiency Anemia
 • Mass lesions: Carcinoma, Large polyps
 • Inflammatory: Reflux esophagitis,
Iron Deficiency Anemia ... rubber bleb nevus syndrome ... • Infectious ... Iron #Deficiency #Anemia ... #Causes #differential
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... Neutropenia - recurrent infections ... Constitutional Syndromes ... Idiopathic • Infections