22 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
syndrome—due to GBM ... hematuria. ... RBC casts in urine ... Nephrotic #Syndromes #Classification ... #Proteinuria #Nephrology
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
- Normal/low Proteinuria ... - ++++ Hematuria ... pressure - Raised Proteinuria ... - ++ Hematuria ... edgarvlermamd - Nephrology
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
the patient has hematuria ... and/or proteinuria ... have glomerular hematuria ... (RBC casts or dysmorphic ... Comparison #Algorithm #Nephrology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
Brown urine - Proteinuria ... and SMA - Can cause ... Bladder Causes ... urinary tract) Causes ... #urology #nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... glomerular bleeding (proteinuria ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology ... if cause not identified
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... sediment - WBC/RBC casts ... proliferative • Anti-GBM ... #Nephrology #Differential ... Diagnosis #Algorithm #Causes
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... nephropathy • Thin GBM ... ) • Anti-GBM ... nephrotic range) proteinuria ... Diagnosis #Algorithm #Causes
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
glomerular disease (hematuria ... , proteinuria) ... Basement Membrane (GBM ... Glomerulonephritis #RPGN #Classification ... Differential #Diagnosis #Nephrology
Algorithm and Differential Diagnosis of Macroscopic Hematuria
Important Historical Elements:
- Painless: suggests malignancy
- Painful: suggests calculi/infection
- Urinalysis:
of Macroscopic Hematuria ... RBC’s, RBC/WBC casts ... , proteinuria suggest ... prostatic) #Diagnosis #EM ... #IM #Urology #Hematuria
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
sterile pyuria, WBC casts ... eosinophiluria, microscopic hematuria ... , mild tubular proteinuria ... , granular casts ... AIN #Algorithm #nephrology