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differential management vasculitis classification ana antibodies antinuclear erythematosus lupus systemic monoclonal sle workup algorithm anemia autoantibodies dermatology diseases hodgkins leukemia
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
cases • Sjögren syndrome ... + 90% • Anti-GBM ... Antineutrophil #antibodies #diagnosis ... #rheumatology # ... diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
c-ANCA - Vasculitis ... granulomatosis p-ANCA ... Anti-GBM - Goodpasture's ... #diagnosis #table ... #rheumatology #
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... - C-ANCA pattern ... rarely PR3 Anti-GBM ... disease - MPO>PR3 ... #Diagnosis #Rheumatology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... Pauci-Immune: - ANCA-positive ... ab, anti-GBM ab ... #differential #diagnosis ... #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Disease (Goodpasture's ... (C-ANCA): GPA > ... (P-ANCA): eGPA, ... #differential #diagnosis ... #algorithm #rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
small vessels - ANCA-associated ... Churg-Strauss syndrome ... Vasculitis #Vessels #Diagnosis ... #Rheumatology # ... Diagnosis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... SLE), Sjogren's Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... glomerulonephritis) • Anti-GBM ... • Cogan Syndrome ... Differential Diagnosis ... #rheumatology #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Cryoglobulinemia (MIXED) • ANCA ... #hematology #rheumatology
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