19 results
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
in cardiorenal syndrome ... hypertrophy • Sodium ... activities • Diuretic ... #Mechanisms #pathophysiology ... #nephrology
Hypernatremia Classification and Features According to Volume Status
 - Hypervolemic hypernatremia - Cushing's syndrome, Primary hyperaldosteronism,
hypernatremia - Cushing's syndrome ... , Loop diuretics ... Postobstructive diuresis ... Diagnosis #Comparison #Table ... #Nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
: SIADH, Renal Sodium ... loss (diuretics ... Cirrhosis, Nephrotic syndrome ... differential #diagnosis #table ... #sodium #nephrology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... Neurological event 2) Sodium ... ) Naturiesis → diuresis ... SaltWasting #SIADH #Pathophysiology ... #diagnosis #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
• Hypovolemic: Diuretics ... osmotic (solute) diuresis ... , Cushing syndrome ... Workup #Algorithm #nephrology ... #sodium
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... and nephrotic syndrome ... and nephrotic syndrome ... #Nephrology #Pharmacology ... #Medications #Table
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
overdose) - Sodium ... foscarnet - Diuretics ... and other loop diuretics ... renal Fanconi syndrome ... differential #diagnosis #nephrology
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
Cirrhosis, Nephrotic syndrome ... , Medications (diuretics ... Algorithm #diagnosis #sodium ... #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... thiazide-sensitive sodium-chloride ... #Pathophysiology ... #nephrology #diagnosis
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Repeat the sodium ... volume loss - diuretics ... • nephrotic syndrome ... Workup #Algorithm #Nephrology