34 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Synthesis of aldosterone ... Trimethoprim) • Aldosterone ... MunerMohamed1 #hyperkalemia ... pathophysiology #pharmacology
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... antagonists • Aldosterone ... glycosides • Aldosterone ... blockers - MCW Nephrology ... MCW_Nephrology #HyperKalemia
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Pentamidine Decreased Aldosterone ... Release: ACE inhibitors ... , K-ATPase and Aldosterone ... happypillsrx/ #Hyperkalemia ... Pathophysiology #Pharmacology
Etiologies of Hypoaldosteronism

Hyporeninemic Hypoaldosteronism (Low Renin, Low Aldosterone)
 - Diabetic Nephropathy 
 - NSAIDs
Non-Hyporeninemic Hypoaldosteronism (Normal
Low Renin, Low Aldosterone ... ) - ACE Inhibitors ... ) - Aldosterone ... #Comparison #Table ... #Causes
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
KBinders #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia ... #Nephrology #Agents
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... • HTN, High Aldosterone ... @priti899 #Hypokalemia ... Diagnosis #Algorithm #causes ... potassium #low #nephrology
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
sodium, which causes ... inhibiting drug classes ... Antagonists), all ... avoid harmful hyperkalemia ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
The Diagnostic Approach to Hyperkalemia
Drugs
 - Amiloride
 - Spironolactone
 - Triamterene
 - Trimethoprim
 - Pentamidine
 -
Diagnostic Approach to Hyperkalemia ... inhibitors Other causes ... insufficiency - Isolated aldosterone ... LMW heparin - ACE-I ... #differential #causes
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
wasting from other causes ... suggests extra-renal causes ... - ↑ Renin ↑ Aldosterone ... - ↓ Renin ↑ Aldosterone ... differential #potassium #nephrology
Diuretic Electrolyte Excretion Effects 
Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid
 - Thiazide Type
+, Mg2+, Ca2+, Cl ... Type - Loop - Aldosterone ... electrolytes #effects #pharmacology ... #comparison #table