10 results
Pathophysiology Of Constriction
Exaggerated Ventricular Interdependence:
 • Limited Cardiac Filling due to Fixed Volume → Septum Shifts
Pathophysiology ... Volume → Septum Shifts ... Intrathoracic-lntracardiac Dissociation ... pericarditis #pathophysiology ... #cardiology #dissociation
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
Oxygen-Hemoglobin Dissociation ... Curve Left Shift ... Temperature Right Shift ... Oxygen #Hemoglobin #Dissociation ... #Curve #pathophysiology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
Oxyhemoglobin Dissociation ... Curve Left Shift ... Oxyhemoglobin #Dissociation ... #Curve #Pathophysiology ... #Left #Right #Shift
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Transcellular Shift ... Algorithm #causes #potassium ... #low #pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... differential #diagnosis #pathophysiology ... #pharmacology #potassium
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pharmacology and Pathophysiology ... contractility (force of contraction ... the cell, serum potassium ... the same site as potassium ... #Pharmacology #Pathophysiology
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
and Hypoxia - Pathophysiology ... 2,3-DPG which shifts ... the oxygen dissociation ... -DPG causing a shift ... the hemoglobin dissociation
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
influx initiating contraction ... occurs initiating contraction ... repolarization CLASS 3 - Potassium ... repolarization - ↓ contraction ... Classification #Classes #pathophysiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
repolarization CLASS 3 - Potassium ... repolarization - ↓ contraction ... Classification #Classes #pathophysiology