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hematology treatment sle druginduced erythematosus product reactions summary systemic algorithm anemia aplastic cerebritis classification coagulation comparison dic differential diffuse dil
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #neurology #rheumatology ... #management #treatment
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... • Systemic Lupus ... • Insect Bites ... #Hematology #Oncology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Manifestations: Malar ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... Leishmaniosis, malaria ... Drugs, Unknown cause ... #management #treatment ... #summary #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... leukostasis syndrome: CNS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... Thromboembolism (7%) • CNS ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... tested include: Malaria ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... tested include: Malaria ... #Transfusion #diagnosis ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... result from low blood ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
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