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diagnosis differential hematology causes hemolysis anemia extravascular intravascular management sle algorithm autoantibodies classification comparison erythematosus mimickers signs symptoms systemic table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation (DIC ... usually IgG) (e.g. lupus ... infection) - Drugs ... • Infections: Malaria ... differential #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
delayed HTR • Drug-induced ... Infections • Malaria ... • PNH • Drug-induced ... • MAHA (TTP, DIC ... Algorithm #Causes #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Lupus (DIL): ... & NPSLE rare, Malar ... Lupusreference #druginduced ... #table #rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... MAHA: TTP, HUS, DIC ... Membrane Defects, Drugs ... Infections/toxins: Malaria ... Urobilinogen #Hemolysis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... AIHA: warm, cold, drug ... Bartonella, Babesia, Malaria ... MAHA: TTP, HUS, DIC ... classification #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Arthritis 69% - Malar ... Lymphadenopathies 7% - Hemolytic ... Mimickers: Drug-induced ... #differential #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... : -10% of all lupus ... & NPSLE rare, Malar ... Lupusreference #DrugInduced ... #Lupus #DIL #rheumatology
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