13 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... coagulation (DIC ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Infections • Malaria ... • MAHA (TTP, DIC ... Diagnosis #Algorithm #Causes ... #Hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
(DIL): • Epidemiology ... rash is rare in DIL ... , SCLE-DIL (terbinafine ... for cutaneous DIL ... for cutaneous-DIL
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Manifestations: Malar ... of SLE versus DIL ... Positive in 60-80% of cases ... life-threatening • Treatment ... #Summary #rheumatology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic Causes ... Bartonella, Babesia, Malaria ... IVIG infusion Intravascular ... : TTP, HUS, DIC, ... classification #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Coagulation (DIC ... Manifestations of DIC ... MAHA: TTP/HUS > DIC ... for bleeding #DIC ... #treatment #management
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
(DIL) • Epidemiology ... & NPSLE rare, Malar ... rash is rare in DIL ... #DIL #rheumatology ... #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Leishmaniosis, malaria ... lymphoma (DLBCL, intravascular ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor and lupus ... Warfarin • Acute DIC ... , disseminated intravascular ... discern these causes ... disease • Acute DIC
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... Causes purpura & ... tested include: Malaria ... Transfusion #diagnosis #management ... #hematology #reactions