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diagnosis hematology anemia causes hemolytic algorithm extravascular intravascular signs symptoms table ana antibodies antinuclear autoantibodies bleeding bruising classification erythematosus hemostasis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... Intrinsic RBC Defects ... • Infections: Malaria ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Hgb - Membrane Defects ... Infections • Malaria ... Extravascular #Differential ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Infections/toxins: Malaria ... Urobilinogen #Hemolysis ... #Differential # ... Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... suspected, consider malaria ... #Anemia #Differential ... Algorithm #workup #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Membrane defects ... Bartonella, Babesia, Malaria ... classification #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... Lymphadenopathies 7% - Hemolytic ... (aPL) 30-45% Differential ... symptoms #mimickers #differential ... #rheumatology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier ... Syndrome • Defect ... #comparison #table ... #differential # ... diagnosis #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
technique used to detect ... healthy adults, and should ... , Drug-induced Lupus ... ANA #patterns #rheumatology ... #diagnosis #differential
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
Features That Differentiate ... associated with rheumatologic ... presentation of systemic lupus ... trapezius ridges or shoulders ... #Presentation #comparison
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 Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... or Qualitative defect ... inhibitor and lupus ... of factor VII should ... coagulation, or defects
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