144 results
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... without platelet ... Eric Strong @DrEricStrong ... - Strong Medicine ... comparison #table #differential
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Indications for Transfusion
Packed RBCs
 • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... Prophylactically for platelet ... not transfuse platelets ... Platelet transfusions ... Management #RBCs #Platelets
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... count and platelet ... 1 or Type 3) — differentiate ... • Platelet flow ... hematology #hemepath #differential
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... Diagnosis Platelet ... Thrombocytosis #Differential ... Diagnosis #causes #Platelets
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
Bleeding and Bruising ... - Differential ... Diagnosis Algorithm ... vs Acquired • Platelet ... #Diagnosis #Algorithm
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Diagnosis Algorithm ... B-symptoms, bruising/bleeding ... anemia, ↑ MCV, ↑/↓ platelets ... #Diagnosis #Algorithm
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... / Bruising - Differential ... Diagnosis Algorithm ... Sequestration Disordered Platelet ... #Diagnosis #Algorithm
Causes of Acquired Platelet Dysfunction

#Acquired #Platelet #Dysfunction #Causes #differential #Diagnosis #hematology
Causes of Acquired Platelet ... #Acquired #Platelet ... Dysfunction #Causes #differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... Count - Differential ... Diagnosis Algorithm ... Thrombocytosis #Platelets ... #Differential #