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liver syndrome algorithm blood hepatitis hepatorenal hrs nephrology product reactions treatment aih alcoholic autoimmune chemistry chronic cirrhosis crisis dic differential
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Kidney Failure Coagulation ... Drug-Induced Liver Injury ... Failure #Cirrhosis #Hepatology ... #diagnosis
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Syndrome (HRS) - Diagnostic ... (Acute: previously ... structural kidney injury ... - No other cause ... HRSAKI #HRSNAKI #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... for alternative causes ... dechallenge • Acute ... #Diagnosis #Algorithm ... #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... Treat primary cause ... #diagnosis #causes ... #treatment #management ... #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Mixed - Check Acute ... Liver Failure (ALF ... • Albumin • Coagulation ... liver #chemistry #diagnosis ... #differential #Hepatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... fever - ACS, AKI ... , acute limb ischemia ... unless worrisome EKG ... #management #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... pattern of liver injury ... , AIH diagnosis ... Viral) Management ... #Management #Hepatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... normal in mild cases ... hemophilia type (e.g ... severity Treatment - Acute ... #hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
hepatitis, or acute ... • Caused by splanchnic ... Diagnosis (Clinical ... Exclude other AKI ... Hepatorenal #Syndrome #Hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
exclude other causes ... Treatment: - Acute ... kidney injury with ... goal of >21 kcal/kg ... #Algorithm #hepatology
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