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diagnosis hematology management causes radiology algorithm bony msk tumors workup chronic classification cll knee lesions leukemia lymphocytic mds myelodysplastic xray
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Increased red cell ... Reticulocytosis/polychromasia ... hyperplasia of bone ... Hemolysis #Hemolytic #Anemia ... #Algorithm #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... • Marrow Aplasia ... RBCs - Sickle Cells ... , Target Cells ... #Differential #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... = Hypocellular bone ... anemia Treatment ... #Anemia #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... with hypocellular bone ... Treatment: • Consider ... stem cell transplant ... #management #treatment
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... cytopenias (usually anemia ... • Bone marrow ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... aplasia • ITP ... microglobulin Treatment ... Warm AIHA • Bone ... diagnosis #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... factor (GCSF) treatments ... blood count with differential ... marrow studies Treatment ... diagnosis #hematology #oncology
Diagram of different types of bone tumors that can occur around the knee on XRay -
different types of bone ... Healed NOF • Giant cell ... ) • Enostosis/bone ... #Differential # ... Radiology #XRay
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Hypoproliferative (i.e. bone ... Hypogonadism • Bone ... marrow failure: Aplastic ... defects (e.g. sickle cell ... #differential #
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
- Differential ... Non-Malignant • Giant Cell ... Tumours #MSK #Differential ... Orthopedics #Causes #Oncology ... #Radiology
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