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Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
produces them when low ... precipitant. 5) treat low ... Complications: • Polydipsia ... DiabeticKetoacidosis #DKA #pathophysiology
Hypoxia and Hypoxemia - Overview Hypoxia - insufficient oxygen delivered to tissues to meet demands Hypoxemia - low
demands Hypoxemia - low ... of hypoxia) - Low ... SvO2 → Low PaO2 ... CaO2 → Low SvO2 ... diagnosis #causes #pathophysiology
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS) Absolute Insulin deficit: - Type I DM:
Pathophysiology ... Electrolyte imbalance → Polydipsia ... #dka #hhs #pathophysiology
Hyponatremia Diagnosis Algorithm UOsm ≥ POsm - Vasopressin-Dependent • UNa < 20 mEq/L - Appropriate (↓ EABV)
Consider: Primary polydipsia ... , Low solute intake
Diagnostic Approach to Hyponatremia Box A: • Normo/hyperosmolar Hyponatremia: Glucose, Mannitol, Glycine, Contrast media, Maltose • Pseudohyponatremia:
Box C: Primary Polydipsia ... , Low Na intake,
Pathyophysiology - hyperglycemic crises in patients with diabetes Key signs/symptoms of HHS/DKA: Both: Polyuria, polydipsia, weight loss,
Pathyophysiology ... Both: Polyuria, polydipsia
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA) DKA is a result of an absolute or relative insulin
Pathogenesis and Pathophysiology ... polyuria, and polydipsia ... details of the pathophysiology ... #Pathophysiology
Volume Based Approach to Hyponatremia Hypovolemic, Serum uric acid >4 • Urine Na <20: Extra-renal losses •
Hypothyroidism, Low ... deficiency, Primary polydipsia ... diagnosis #sodium #low
Causes of Polyuria - Differential Diagnosis Excess Intake of Water: • Primary polydipsia (a.k.a. "psychogenic polydipsia") •
Water: • Primary polydipsia ... "psychogenic polydipsia ... • Central Dl (Low
Hyponatremia - Differential Diagnosis Algorithm ADH Independent: • Tea and Toast Syndrome, Beer Potomania - Low solute
Beer Potomania - Low ... • Psychogenic Polydipsia
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