1525 results
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
Aspergillus - Other positives ... infection (IFI) in hematologic ... cut-offs defined in clinical ... in HM • False positives ... BAL GM does not differentiate
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... odds of having positive ... likelihood of negative clinical ... #Bandemia #differential ... neutrophil #WBC #CBC #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... dehydrogenase • Positive ... younger pts) Differential ... hemolytic #anemia #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Immunohistochemical studies (to differentiate ... characteristically CD30 positive ... and usually CD15 positive ... classification #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Pancytopenia - Differential ... Infiltration: • Hematologic ... and non-hematologic ... #Neutropenia #Differential ... Algorithm #Causes #Hematology
Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Non malignant hematologic ... states • Non-hematologic ... Thrombocytosis #Differential ... Algorithm #Causes #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Features of hematologic ... #Leukocytosis #Differential ... Diagnosis #Algorithm #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
mediated - DAT: IgG positive ... , C3 positive or ... IgG negative, C3 positive ... Pathophysiology #diagnosis #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
autoantibodies: positive ... • Blood smear: Differential ... → schizocytes, Positive ... management #treatment #rheumatology