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diagnosis differential rheumatology algorithm causes erythematosus generalized lupus management signs symptoms systemic vasculitis chronic comparison criteria eularacr fatigue grandmal gravis
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... an autoimmune disorder ... rheumatoid arthritis, SLE ... Ocular- 50%: Ptosis ... diagnosis #management #neurology
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Polyneuropathy, ALS), NMJ disorder ... (Myasthenia, LEMS ... body-), PMR, RA, SLE ... Diagnosis #causes #neurology
Ptosis - Differential Diagnosis Framework Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
Myasthenia gravis ... Neurogenic Ptosis - Neurologic ... Horner syndrome • Myasthenia ... Congenital Ptosis - Absence ... Syndrome #Ptosis #neurology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Arthritis • SLE ... Pulmonary Disease Neurologic ... Parkinson's • Myasthenia ... • Somatization Disorder
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... prognosis • Nodular ... - 5% RS cells absent ... Lymphoproliferative #Disorders ... #Classification
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
desaturation, Scotoma, Ocular ... Comorbid autoimmune disorders ... Sjögren syndrome, Myasthenia ... Manifestations #diagnosis #neurology
Generalized Seizures and Pseudoseizures Generalized seizures "are conceptualized as originating as some point within, and rapidly engaging,
toxic or metabolic disorder ... grand mal) - Absence ... psychological disorder ... Pseudoseizures #GrandMal #Classification ... #Diagnosis #Neurology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... least 2 joints • Neurologic ... #EULARACR #Classification ... #Criteria #SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Erythematous, macular ... ) • Endocrine disorders ... dysfunction, and mood disorder ... endocarditis • Valvular disorders
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Focal inflammatory disorder ... : decreased or absent ... Evaluate for NMO, SLE ... : - SLE - Neurosarcoidosis ... diagnosis #management #neurology
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